Brazil, Chernobyl, & An Answer

My 52 Weeks With Christie: A 2022 Revisit to The Pale Horse Part 3

On September 13, 1987 a security guard failed to show up for his shift at an abandoned medical clinic in Goiania, Brazil. This seemingly unremarkable event set into motion events that would eventually cumulate into a mass cesium-137 radiation event — second only in size and severity to Chernobyl.

On that fateful day, taking advantage of the guards absence, a pair of men absconded with the deserted clinic’s tele-therapy device. Not knowing what they’d stolen, the two begun disassembling the steel and lead liners in hopes they’d fetch a good price from the salvage yards. Unsurprisingly, they both rapidly begun exhibiting signs of radiation sickness and burns. Which prompted one of the men to visit a doctor — who put his symptoms down as food poisoning. Whilst he was told to go home and rest, his friend continued to break up the device. Eventually, he managed to puncture the housing’s heart with a screwdriver…and discovered a deep blue glowing substance residing inside.

Getting sicker by the minute the thieves sold the perforated device to a salvage yard.

That night the new owner, spying a beautiful blue glow emanating from his backyard, decided to bring the device inside his house. Using a screw driver he widened the hole slightly, and found a glittering blue gem inside. Scraping the ‘gem’ he managed to dislodge and extract several pieces of the cesium-137. He then gave away the twinkling pieces, about the size of a grain of rice, to his favorite family members and neighbors for good luck.

However, after his wife grew sick, the same day he’d begun fiddling around with and gifting people with the twinkling blue dust, he sold it to another scrapyard….spreading sickness, along with radioactive dust, even further afield.

Finally, the now ailing wife of the first salvage yard owner noticed how everyone who’d come into contact with the device or it’s pretty innards grew gravely ill — she retrieved the device from the other salvage broker and took it to a hospital. Where a doctor figured out they weren’t suffering from food poisoning or a cold but from radiation sickness. 

The doctor then persuaded the Brazilian government to intervene.

In the end, well over 100,000 people were tested for exposure to cesium-137, 249 were found to have been exposed and amongst the 249 — there were 44 serious cases which cumulated in 4 – 7 deaths (my source materials are conflicted on this number), including the wife who’d initially alerted authorities. 

(A photo taken in 2020 by Gustavo Leighton of an area in Goiania — though not of the cesium-137 contaminated area. I just though people might like to see how beautiful the area is!)

Again, how does this 1987 tragedy influence my Pale Horse research? Turns out, this was the first large scale, systematic test of the efficacy of Prussian Blue treatment in humans. 

Now in possession of another firm date, which I must admit was far more recent than I’d ever dreamt when I begun my informal inquiry, I started scouring the Library’s database for more modern research papers. 

And struck gold. (Whilst the plumbers realized several fixtures in the house hadn’t been properly installed….)

In Mexico from 1978 – 1986, where thallium based rat poisons hadn’t been banned, 50 cases of exposure due to an accident, attempted suicide, or murder were recorded. Of the 50 — 26 were treated with Prussian Blue and as expected those patients recovered significantly faster. (The other 24 were treated with the standard non-Prussian Blue medicines.) 

Another study, held from 1990 – 1995, administered Prussian Blue to cattle in areas of the Ukraine, Belarus, and Russia hardest hit by the 1986 Chernobyl disaster. Scientists hoped to reduce the lingering cesium-137 from the food chain (i.e. milk and meat) by treating the cows with Prussian Blue. Which it did. (It also proved to be cost effect way of doing so.)

How? 

Turns out Prussian Blue clears up a case of mistaken identity. 

When cesium-137, radioactive thallium, or regular thallium enters your body — their ions fool your body, for a hot second, into thinking they’re potassium ions. Since we need potassium for all kinds of important functions, our body’s are keen on absorbing it — which is how the poisons get a foot hold in your system. Now the body isn’t bamboozled for very long, and when it figures out the toxic ions aren’t actually potassium, they get unceremoniously dumped into the intestines….Unfortunately, a large number of the deadly ions fool the body once again and get reabsorbed. 

The binary cycle — which ends with either recovery (if the dose was small enough) or death (more often than not) — played out over and over again. Until a scientist came up with a theory, exposed some rats to cesium-137, and then treated some with pharmaceutical grade Prussian Blue in 1963.

The crystalline structure of the insoluble version of Prussian Blue trapped the cesium-137 by exchanging its own potassium ions for the poisonous ones. Because of Prussian Blue’s strong affinity for cesium-137 the pigment held firmly onto to the poisonous ion — even through the intestine. So the treated rats end up whizzing and pooping out the toxin much faster than their traditionally treated and non-treated counterparts.

Armed with even more info I turned, once again, to the library database….and found, in a single line of a chemistry textbook, a name. (And the plumbers informed me the five feet of cast iron sewer line, which didn’t get a new liner, was the source of our continuing back-up problems — needed replacing. Cue more apocalyptic sounds echoing up from the underside of our house.)

Nigrovic.

Dr. Vladimir Nigrovic.

Who got the Prussian Blue ball rolling in 1965 when he published a paper, Retention of Radiocaesium By The Rat As Influenced By Prussian Blue And Other Compounds, informing the world of his findings. (Born in Yugoslavia in 1934, Dr. Nigrovic emigrated to the U.S. and went on (after his Prussian Blue find) to have an impressive career in medicine, academia, and as a teacher. He sadly passed away in 2008.) Four years later, in 1969, a German pharmacologist named Horst Heydlauf of Karlsruhe suggested Prussian Blue as an antidote for thallium poisoning.

And there it was, the answer I sought — the names of the two scientists who figured out a pigment could help those poisoned by cesium-137 and thallium. 

You’d think their names would be easier to suss out! 

Now, I didn’t discover how they came up with their theories, if they were indeed inspired by The Entombment of Christ by Pieter van Der Werff (the first known painting to have Prussian Blue in its creation) or by an offhand comment from a colleague but either way, their find has saved live all over the world.

And, having finally answered my own question, my search was over.

And so too was the trial and tribulations of our house’s plumbing problems (knock on wood). It only took three weeks, the rapid depletion of our savings, and several holes in our garden before we could do some nerve wracking loads of laundry and dishes….On the upside I now fully appreciate the luxury of running water, a fully functioning sewer line, and plumbers! 

(Whom I fervently hope I don’t need to hire again anytime in the near future!)

A.Miner©2022

Thallium, Rat Poison, & Poisoning

My 52 Weeks With Christie: A 2022 Revisit to The Pale Horse Part 2

In fairness to all the scientists studying Prussian Blue, uncovering its curative properties couldn’t really come about until someone discovered Thallium. A feat which finally happened….157 years after Prussian Blue’s in a moment of scientific synchronicity. 

As it turned out both Sir William Cooks and Claude-Auguste Lamy independently observed, tested, and published papers about a new element in 1861. (They also presented their find, in separate demonstrations, at the Great London Expo in 1862.  Which led to a massive brouhaha as Lamy was awarded a medal for the discovery and Crooks was not.) In any case, whilst Cooks got to name the new silvery-white metal (after the Greek word thallos — in honor of the bright green flame it produced when burned), Lamy holds the dubious distinction of being the first confirmed case of thallium poisoning.

(Sir William Crookes on the left — The Interior of The Great London Expo in the center — Claude Auguste Lamy on the right)

Apparently, during Lamy’s pursuit and study of the newest heavy metal on the periodic table, he began suffering lower limb pain and weakness. Theorizing thallium as the source of his health problems, Lamy set about testing his notion. 

(***Trigger Warning*** I’ve no clue what Lamy had against puppies.) 

Dissolving 5 grammes of thallium sulphate in milk, Lamy offered the polluted mixture to two two-month-old puppies. Who, after taking an initial drink, refused to swallow another ounce of Lamy’s lethal potion. Leaving the remainder in the yard overnight, probably hoping the puppies would lap up more poison (the jerk), Lamy went outside the following morning and discovered the dish empty.

Taking a good look around his yard, Lamy quickly determined that an adult dog, two hens, and six ducks had unexpectedly finished off the puppy’s foul brew. Over the next several hours, all the unfortunate animals, puppies included, began exhibiting signs of depression, fatigue, paralysis of lower limbs, convulsions, pain, and eventually death. When Lamy performed a necropsy on the corpses, none of the animal’s organs showed any significant signs of poison. However, when Lamy subjected the animal’s organ tissue to spectral analysis, the tell-tale vibrant green flame gave thallium’s presence away. 

Wanting to make sure of his findings, Lamy gave another luckless two-month-old puppy a grain and a half of thallium sulfate. When the poor thing died forty hours later, Lamy finally felt confident enough to infer that thallium sulfate was a potent poison. 

When Lamy published his findings in 1863, he made sure to tack on a warning to anyone thinking of using this easily dissolvable and nearly tasteless toxin for nefarious purposes, “…there is not a poison that can be traced with more certainty…than this.” (Cork Examiner Sept. 8, 1863; issue 4333.)

Super, so I now knew when and how people figured out you shouldn’t lick a lump of thallium. However, I still hadn’t found a link to Prussian Blue. (And BTW – The fact Lamy knew thallium sulfate is nearly tasteless makes me wonder if he didn’t do a taste test and inadvertently poison himself.) 

Stymied, I decided to reread The Pale Horse. (Plus, as we didn’t have any running water or plumbers in the house for a few days, and I needed something to do.) Whereupon, thanks to my early research, another detail stuck in my craw. 

Assuming Christie set The Pale Horse in and around 1961 (the book’s publication year) and Lamy had already established thallium’s lethalness back in 1863. Then why was Rhoda Despard (Mark Easterbrook’s cousin) using a thallium cream to remove a patch of hair on her dog in order to cure their case of ringworm? Especially since, over the intervening ninety-eight years, newspapers had provided ample proof that people shouldn’t have access to thallium. 

Don’t believe me? 

Well, amongst other infamous stories reported in the papers betwixt 1863 and 1961 there were the accidental deaths of three little boys in 1929 at St. John’s Hospital (Leicester Square) from a miscalculated dose of thallium meant to cure their case of ringworm. A few years later, in 1935, a New York father of five named Fredrick Gross was accused (and ultimately found not guilty) of murdering his wife and four of his five children with thallium-laced hot chocolate. Three years later, in 1938, Austria executed Martha Marek by guillotine for murdering her husband, daughter, aunt, and two boarders with thallium-based rat poison. Finally, there’s Australia’s infamous ‘Thallium Craze’ — which all started thanks to an infestation of rats and mice around the country (but mainly in Sydney) in the 1950s. Since no one is keen on sharing their abode with rodents, retailers stocked large quantities of thallium-based rat poison on their shelves. The easy access and perfect purchasing camouflage coupled with high profile poisoning trials of Yvonne Fletcher, Caroline Grills, Veronica Monty, and Beryl Hague — led to at least one hundred people finding themselves at the wrong end of a thallium-laced cups of tea, cakes, and cocktails.

(In fairness to Rough On Rats, it doesn’t actually contained thallium — it was an arsenic based rat poison. Which isn’t any less lethal. But I wanted to show how prevalent this style of pest control substance was back in the 1880’s with this newspaper advertisement. Plus, Rough On Rats was cited in the poisoning cases of Ceely Rose and Ada Applegate — to name just a couple of cases.)

However, none of the articles I found ever mentioned the survivors, and there were a few, being treated with Prussian Blue. Nor did Christie write about The Pale Horse’s heroine, Ginger, being treated with the stuff during her hospital stay either. And since our authoress wrote about the poison in such detail it saved a number of lives over the years — I can’t imagine she would’ve omitted its antidote. 

So I did what I should’ve done in the first place, after smacking myself in the head and saying ‘Doh!’ — I googled ‘Prussian Blue AND antidote’ — whereupon I made a startling discovery.

(Now, I probably should’ve started my search with Wikipedia. However, armed with a newly minted library e-card, I was fully committed to the newspaper/scientific paper/government org rabbit hole in which I’d already leapt and didn’t think of it….Plus, my hyper-focus search allowed me to block out the apocalyptic sounds emanating from under the house.)

The FDA didn’t approve Prussian Blue as a treatment for thallium poisoning until 2008, and the World Health Organization only added it to its Essential Medicines list in 1999.  Switching back to the Library’s digital database, I found a number of helpful research papers corroborating and elaborating upon the aforementioned info. 

I also learned Prussian Blue is an antidote for Cesium-137 poisoning as well…and this little tidbit cracked the informational floodgates wide open. (Thankfully, my kitchen floor remained dry….which is more than can be said about the bathroom’s.)

A.Miner©2022

2014 Review Part 2:The Princess Bride, Iocane Powder, & Thallium

My 52 Weeks With Christie: My 2014 The Pale Horse Review

Interesting Facts: **Spoiler Kind Of** While I reveal the murder weapon this will not give you the delivery method or the culprit!**

Hello. My name is Inigo Montoya. You have killed my father; prepare to die!””

Alas I cannot relate Christie to this quote. (I am hoping for that day.) However, The Pale Horse does contain a slightly more sinister similarity to this 1987 film classic. In The Princess Bride (I am speaking of the movie here not the book, as I have not read it yet, blasphemer I know) Vizzini (played by Wallace Shawn) claims, “What you do not smell is called iocane powder. It is odorless, tasteless, dissolves instantly into liquid and is among the more deadlier poisons known to man.” The perfect poison for a battle of wits or for the occasional mysterious murder. Happily enough this iocane powder is completely fictional, a poison like that would be disastrous if obtained by the wrong person…

While The Princess Bride relies on a fictional poison to move the story along, Christie decided to use a real one in The Pale Horse. And just like in The Princess Bride this poison is orderless, colorless, tasteless, difficult to trace, hard to diagnose and dissolves easily in liquids.

Making Thallium a perfect poison — so to speak.

Though, unlike iocane powder, you cannot build up a tolerance to thallium. Thus making it less desirable for a duel of wits, as generally it’ll kill you stone dead.

But I digress.

Thallium is a highly toxic metal and like arsenic was once used as a rat poison and some medicines (Seriously there has to be some sort of symbolism to the number of people poisoned by something meant to kill rats…) If administered in large enough doses thallium can kill with in 24 to 48 hours after it is administered. However, poisoners generally dole it out in smaller doses, invoking a whole other set of symptoms. Which in turn mimic a whole plethora of other ailments. So when death occurs it appears to be natural causes.

The one tell thallium possesses? Rapid and clumpy hair loss.

Christie’s description of said symptoms in The Pale Horse is so good, it is credited with saving a number of lives. In 1975 a woman sent a letter to Christie stating she figured out her husband was poisoning her with thallium after reading the book. Second, a hospital nurse in 1977 diagnosed a baby’s illness (due to thallium) while reading the book. Most astonishing The Pale Horse is credited with stopping a serial killer dubbed The Teacup Poisoner. Graham Fredrick Young was convicted in 1972 for murdering two of his fellow co-workers while poisoning seventy others in the factory where he worked. As the story goes, a doctor consulting for Scotland Yard correctly identified the poison being used by Young thanks to Christie’s mystery.

On a complete side note the absolutely best treatment for thallium poisoning is a pigment called Prussian Blue (taken in pill form). It is even better than activated charcoal in removing the heavy metal from the victims system – due to the complex chemical nature.

Not sure what Prussian Blue is?

It is the pigment used to make blueprints, well, blue! It is also one of the colors which makes Vincent van Gogh’s painting Starry Night so vivid. It was one of the very first synthetic pigments to be created, around 1706. (FYI — do not eat blue prints if you think someone is poisoning you. Seriously there is lab grade Prussian Blue without the other chemical associated with paper & paint!)

Christie is often called the Queen of Poisons and The Pale Horse I think is the flawless jewel set in this crown.

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AmberMiner©2014